{"id":55104,"date":"2026-03-17T09:02:44","date_gmt":"2026-03-17T14:02:44","guid":{"rendered":"https:\/\/www.inovestor.com\/?p=55104"},"modified":"2026-03-17T09:02:44","modified_gmt":"2026-03-17T14:02:44","slug":"13-u-s-large-cap-healthcare-stocks-with-stable-returns-and-positive-earnings-revisions-for-defensive-positioning-in-uncertain-markets","status":"publish","type":"post","link":"https:\/\/www.inovestor.com\/en-ca\/2026\/03\/13-u-s-large-cap-healthcare-stocks-with-stable-returns-and-positive-earnings-revisions-for-defensive-positioning-in-uncertain-markets\/","title":{"rendered":"13 U.S. Large-cap Healthcare Stocks with Stable Returns and Positive Earnings Revisions for Defensive Positioning in Uncertain Markets"},"content":{"rendered":"<p><strong>What are we looking for?<\/strong><\/p>\n<p>Healthcare has long been considered one of the most resilient defensive sectors in equity markets as demand for healthcare services, pharmaceuticals, and medical devices tends to remain stable regardless of the broader economic environment.<\/p>\n<p>Given the current uncertain macroeconomic environment driven by geopolitical tensions, oil market volatility contributing to inflationary concerns, and technological shifts toward artificial intelligence raising fears of labor market disruptions, defensive stocks may offer opportunities for investors seeking capital preservation. Therefore, we are looking for healthcare stocks that offer the investors stability and strong profitability.<\/p>\n<p><strong>The screen<\/strong><\/p>\n<p>We screened the U.S. healthcare universe (as classified under the Global Industry Classification Standard) with market capitalization greater than US$25 billion, and ranked companies in the top 25<sup>th<\/sup> percentile based on the following criteria:<\/p>\n<ul>\n<li><strong>five<\/strong>-year average return on invested capital (ROIC) greater than 15 per cent &#8211; indicating companies that generate strong returns relative to the invested capital;<\/li>\n<li>positive<strong> three<\/strong>-month earnings revisions\u2013 positive revisions indicate improving analyst expectations and strengthening earnings outlook;<\/li>\n<li><strong>ten<\/strong>-year EBITDA standard deviation below 15 per cent \u2013 this metric allows us to identify companies with more stable operating earnings over time.<\/li>\n<\/ul>\n<p>For informational purposes, we also include price-to-earnings (P\/E), one-year price return and dividend yield.<\/p>\n<p><strong>More about Inovestor<\/strong><\/p>\n<p>For 25 years as a pioneering Canadian fintech, we\u2019ve consistently pushed the boundaries to empower investment advisers with advanced, easy-to-use investment strategies. Discover more about our journey and offerings on our\u00a0<a href=\"https:\/\/www.inovestor.com\/en-ca\/\">website<\/a>.<\/p>\n<table width=\"576\">\n<tbody>\n<tr>\n<td width=\"64\">TICKER<\/td>\n<td width=\"64\">Name<\/td>\n<td width=\"64\">MKT VALUE ($US BIL.)<\/td>\n<td width=\"64\">5Y ROIC(%)<\/td>\n<td width=\"64\">3M EARNING REV.<\/td>\n<td width=\"64\">10Y EBITDA STD (%)<\/td>\n<td width=\"64\">P\/E<\/td>\n<td width=\"64\">1Y PRICE RTN (%)<\/td>\n<td width=\"64\">DIV. YLD. (%)<\/td>\n<\/tr>\n<tr>\n<td>CAH-N<\/td>\n<td>Cardinal Health Inc<\/td>\n<td>51.1<\/td>\n<td>22.3<\/td>\n<td>5.3<\/td>\n<td>11.6<\/td>\n<td>22.6<\/td>\n<td>71.9<\/td>\n<td>0.9<\/td>\n<\/tr>\n<tr>\n<td>ZTS-N<\/td>\n<td>Zoetis Inc<\/td>\n<td>48.8<\/td>\n<td>24.7<\/td>\n<td>3.5<\/td>\n<td>2.5<\/td>\n<td>18<\/td>\n<td>-27.8<\/td>\n<td>1.8<\/td>\n<\/tr>\n<tr>\n<td>ISRG-Q<\/td>\n<td>Intuitive Surgical Inc<\/td>\n<td>167.7<\/td>\n<td>21.2<\/td>\n<td>3.2<\/td>\n<td>10.6<\/td>\n<td>52.9<\/td>\n<td>-1<\/td>\n<td>0<\/td>\n<\/tr>\n<tr>\n<td>EW-N<\/td>\n<td>Edwards Lifesciences<\/td>\n<td>47.5<\/td>\n<td>22<\/td>\n<td>3<\/td>\n<td>7.7<\/td>\n<td>32<\/td>\n<td>20.4<\/td>\n<td>0<\/td>\n<\/tr>\n<tr>\n<td>AMGN-Q<\/td>\n<td>Amgen Inc<\/td>\n<td>197.4<\/td>\n<td>22<\/td>\n<td>2.4<\/td>\n<td>6.6<\/td>\n<td>16.8<\/td>\n<td>17.1<\/td>\n<td>2.8<\/td>\n<\/tr>\n<tr>\n<td>RMD-N<\/td>\n<td>ResMed Inc<\/td>\n<td>33.6<\/td>\n<td>19.5<\/td>\n<td>1.7<\/td>\n<td>7.9<\/td>\n<td>22.5<\/td>\n<td>5.1<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>IDXX-Q<\/td>\n<td>IDEXX Laboratories Inc<\/td>\n<td>45.7<\/td>\n<td>39.2<\/td>\n<td>1.3<\/td>\n<td>6.7<\/td>\n<td>46<\/td>\n<td>41.2<\/td>\n<td>0<\/td>\n<\/tr>\n<tr>\n<td>MCK-N<\/td>\n<td>McKesson Corporation<\/td>\n<td>115.2<\/td>\n<td>31.6<\/td>\n<td>0.9<\/td>\n<td>9.5<\/td>\n<td>25<\/td>\n<td>46.2<\/td>\n<td>0.3<\/td>\n<\/tr>\n<tr>\n<td>WAT-N<\/td>\n<td>Waters Corp<\/td>\n<td>28.1<\/td>\n<td>27.8<\/td>\n<td>0.9<\/td>\n<td>4.3<\/td>\n<td>21.8<\/td>\n<td>-21.4<\/td>\n<td>0<\/td>\n<\/tr>\n<tr>\n<td>UNH-N<\/td>\n<td>UnitedHealth Group Inc<\/td>\n<td>256<\/td>\n<td>15.7<\/td>\n<td>0.8<\/td>\n<td>8.7<\/td>\n<td>17.3<\/td>\n<td>-41.4<\/td>\n<td>3.1<\/td>\n<\/tr>\n<tr>\n<td>JNJ-N<\/td>\n<td>Johnson &amp; Johnson<\/td>\n<td>582<\/td>\n<td>22.1<\/td>\n<td>0.7<\/td>\n<td>6<\/td>\n<td>22.4<\/td>\n<td>48.2<\/td>\n<td>2.2<\/td>\n<\/tr>\n<tr>\n<td>A-N<\/td>\n<td>Agilent Technologies<\/td>\n<td>31.5<\/td>\n<td>19.3<\/td>\n<td>0.6<\/td>\n<td>8.1<\/td>\n<td>19.8<\/td>\n<td>-5<\/td>\n<td>0.9<\/td>\n<\/tr>\n<tr>\n<td>ABT-N<\/td>\n<td>Abbott Laboratories<\/td>\n<td>187.7<\/td>\n<td>19.2<\/td>\n<td>0.1<\/td>\n<td>13.2<\/td>\n<td>21<\/td>\n<td>-16.8<\/td>\n<td>2.3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>What we found<\/strong><\/p>\n<p><strong>Resilient healthcare companies with stable operating performance<\/strong><\/p>\n<p><strong>Cardinal Health Inc (CAH-N)<\/strong> is a healthcare services and products company that distributes pharmaceuticals and medical products to pharmacies, hospitals and healthcare providers. The company stands out with the highest positive earnings revision of 5.3 per cent in our screen, reflecting strong analyst earning expectation. It also demonstrates impressive profitability with a ROIC of 22.3 per cent, while its one-year price return of 71.9 per cent signals momentum. The company represents an attractive opportunity for investors seeking momentum, quality earnings and improving earnings expectations.<\/p>\n<p><strong>Zoetis Inc<\/strong> <strong>(ZTS-N) <\/strong>is a global animal health company that discovers, develops, manufactures and commercializes medicines, vaccines and diagnostic products for livestock and companion animals. The company stands out with lowest 10-year EBITDA standard deviation of only 2.5 per cent, representing exceptional stability in its operating earnings. Zoetis also exhibits the highest rank in our screen while trading at a decent P\/E ratio of 18.0x. The company provides an opportunity for investors seeking earnings stability at a reasonable valuation.<\/p>\n<p><strong>Intuitive Surgical Inc (ISRG-Q)<\/strong> develops robotic-assisted surgical systems that enable minimally invasive procedures across a variety of medical specialties. The company reports the third-highest earnings revision of 3.2 per cent and a strong five-year average ROIC of 21.2 per cent, reflecting efficient capital deployment. The company continues to benefit from the long-term adoption of robotic-assisted surgery technologies supporting future growth potential. However, investors should note that it trades at the highest P\/E ratio in our screen at 52.9x, which may warrant caution for valuation-sensitive investors.<\/p>\n<p>Investors are advised to do further research before investing in any of the companies listed in the accompanying table.<\/p>\n<p><em>For more details about these stocks, subscribe to the Inovestor for Advisors platform for free.<\/em><\/p>\n<p><em>Anuj Anand, MBA, LLM is an Investment Analyst at Inovestor.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>What are we looking for? Healthcare has long been considered one of the most resilient defensive sectors in equity markets as demand for healthcare services, pharmaceuticals, and medical devices tends to remain stable regardless of the broader economic environment. Given the current uncertain macroeconomic environment driven by geopolitical tensions, oil market volatility contributing to inflationary [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-55104","post","type-post","status-publish","format-standard","hentry","category-number-cruncher"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.3 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>13 U.S. Large-cap Healthcare Stocks with Stable Returns and Positive Earnings Revisions for Defensive Positioning in Uncertain Markets - Inovestor<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.inovestor.com\/en-ca\/2026\/03\/13-u-s-large-cap-healthcare-stocks-with-stable-returns-and-positive-earnings-revisions-for-defensive-positioning-in-uncertain-markets\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"13 U.S. Large-cap Healthcare Stocks with Stable Returns and Positive Earnings Revisions for Defensive Positioning in Uncertain Markets\" \/>\n<meta property=\"og:description\" content=\"What are we looking for? 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Healthcare has long been considered one of the most resilient defensive sectors in equity markets as demand for healthcare services, pharmaceuticals, and medical devices tends to remain stable regardless of the broader economic environment. 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